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Contraindicated (1)pentobarbital will lower the level or effect of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is accountable for the development and elimination of cariprazine's active metabolites.pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabo